Bioniche's Mycobacterial Cell Wll-DNA Complex shows anticancer activity in rats

By Lisa Kerner

Erie, Pa., May 24 - Bioniche Life Sciences Inc. said preclinical data demonstrates that repeated intraperitoneal administration of its proprietary Mycobacterial Cell Wall-DNA Complex (MCC) is well tolerated and results in significant anticancer activity against peritoneal colon carcinomatosis in rats.

The data was presented at the Cambridge Healthtech Institute's Fifth International World Pharmaceutical Congress in Philadelphia, according to a company news release.

In a 12-month study evaluating the survival efficacy of MCC suspension, only 10% of untreated control rats were still alive, while 70% of rats were still alive after nine intraperitoneal administrations of 0.625 mg MCC suspension.

Bioniche said comparable anticancer activity was seen at higher doses (1.25 and 2.5 mg).

"This study demonstrates that MCC suspension has a remarkably long duration of anticancer activity in rats having experimental colon metastases in the peritoneum," chief scientific officer Nigel C. Phillips said in the release.

"Treatment options for therapeutic management of tumors presented in the peritoneal cavity are currently limited. There is an opportunity for using MCC suspension for treatment of patients with peritoneal metastasis from colorectal cancer."

Officials said the product, trademarked Urocidin, is under evaluation as an intravesical treatment of urinary bladder cancer.

The Food and Drug Administration approved Bioniche's two multicenter phase 3 clinical trials of Urocidin in the treatment of patients with non muscle invasive bladder cancer.

Located in Belleville, Ont., Bioniche develops proprietary cancer therapies.

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