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Medarex, Massachusetts Biologic Labs begin phase 2 trial in diarrhea
By Lisa Kerner
Charlotte, N.C., Sept. 6 - Medarex, Inc. and The Massachusetts Biologic Laboratories began a randomized, double-blind, placebo-controlled phase 2 clinical trial of CDA-1 (or MDX-066) and MDX-1388 for the treatment of C. difficile-associated diarrhea.
Up to 200 patients with the illness will be enrolled in the single-dose trial of the two novel fully human monoclonal antibodies.
"C. difficile-associated diarrhea is a growing and potentially serious epidemic, particularly in the 20% to 50% of hospitalized patients who relapse after receiving antibiotic treatment," Massachusetts Biologic Laboratories director Donna Ambrosino said in a news release.
Medarex is a Princeton, N.J., biopharmaceutical company. Massachusetts Biologic Laboratories is part of the University of Massachusetts Medical School in Jamaica Plain, Mass.
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