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Published on 2/23/2006 in the Prospect News Biotech Daily.

LabCorp to commercialize Yale's blood testing technology for ovarian cancer

By Lisa Kerner

Erie, Pa., Feb. 23 - Laboratory Corp. of America Holdings said it has entered into an exclusive license agreement with Yale University to commercialize the university's new blood testing technology for epithelial ovarian cancer (EOC), the fourth most common cancer in U.S. women and the leading cause of gynecological cancer death.

Under the terms of the agreement, Yale will receive signing, milestone and royalty fees, according to a company news release. Additional terms were not disclosed.

"Ovarian cancer is one of the most difficult cancers to detect, especially in the earliest stages when it is more treatable," LabCorp executive vice president, chief scientific officer and medical director Myla P. Lai-Goldman said in the release.

"Consistent with our oncology strategy to fulfill unmet medical testing needs, LabCorp continues to dedicate resources to identifying and commercializing tests to help discriminate earlier between disease-free and cancer patients."

The Yale technology for EOC is based on a collection of known serum proteins associated with cancer biology, officials said. Each protein marker is analyzed using a routine Elisa assay, followed by a statistical analysis to score the combined results.

Multiple statistical analyses on preliminary sample sets for a population of 206 women, including 24 patients with early stage EOC and 76 with later stage EOC, showed favorable sensitivity and positive predictive value, the company said.

The Yale University Office of Cooperative Research manages intellectual assets created at Yale. The university is located in New Haven, Conn.

LabCorp, located in Burlington, N.C., commercializes new diagnostic technologies and embraces genomic testing.


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