American Bioscience says injectable Abraxane shows improved activity versus solvent-based Taxotere

By Elaine Rigoli

Tampa, Fla., April 4 - American Pharmaceutical Partners, Inc. and American Bioscience, Inc. announced the presentation of data at the annual meeting of the American Association of Cancer Research that investigated the potential of improved safety and activity of Abraxane versus Taxotere (docetaxel injection) in the preclinical setting.

Abraxane for injectable suspension (paclitaxel protein-bound particle for injection) in a preclinical dose-ranging study across various tumor models showed improved activity versus solvent-based docetaxel injection (Taxotere), according to a news release.

Taxanes (paclitaxel and docetaxel, Taxol and Taxotere, respectively) are among the most widely used chemotherapeutic agents; however, conventional forms of these agents cannot be administered without the combination of toxic solvents, the release said.

Solvents cause significant additional side effects beyond those associated with the chemotherapeutic agent.

The study found that Abraxane was nontoxic up to 120 mg/kg. In contrast, Taxotere showed a dose dependent weight loss for 15-50 mg/kg with the maximum tolerated dose at 15 mg/kg.

Abraxane was more active than Taxotere with demonstrated tumor growth inhibition at 15 mg/kg in four of five models, the release said.

The study suggests that Abraxane was more effective, or equally effective, at a submaximum tolerated dose (MTD) compared with Taxotere at its MTD in four of five models, concluding that a clinical study of Abraxane versus Taxotere was warranted.

A second preclinical study applied nab technology to docetaxel and in preclinical models of colon cancer compared nab-docetaxel with Taxotere (docetaxel injection).

The study suggested that nab-docetaxel showed significantly greater anti-tumor activity against colon tumor versus Taxotere and despite a 50% higher dose demonstrated equivalent safety to Taxotere.

American BioScience is a privately held biotechnology company based in Los Angeles.

American Pharmaceutical is a specialty drug company based in Schaumburg, Ill.

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