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Alfacell presents positive Onconase non-small cell lung cancer data
By Jennifer Chiou
New York, Oct. 19 - Alfacell Corp. said it is presenting new data showing Onconase used against non-small cell lung cancer inhibited tumor growth.
The report is being made at the 47th Annual Meeting of the American Society of Therapeutic Radiology and Oncology in Denver.
Intae Lee of the University of Pennsylvania's department of radiology will present a report titled "The Enhanced Efficacy Of Cisplatin And Carboplatin By The RNase Onconase On A549 Human Lung Cancer Xenografts Of Nude Mice."
"In these studies, we observed several events, including whether apoptosis was induced by Onconase; whether Onconase could sensitize the efficacy of chemotherapeutic agents cisplatin and carboplatin, and the changes in tumor volume after treatments with Onconase in combination with either cisplatin or carboplatin," Lee said in a news release.
"The data from our research indicates that Onconase alone inhibited the tumor growth of A549 human NSCLC cells and induced apoptosis of those cells.
"Onconase also enhanced the cytotoxic effects of cisplatin and carboplatin when both drugs were simultaneously administered and when cisplatin or carboplatin was added after Onconase, and increased the cisplatin-induced tumor growth delay.
"Finally, and importantly, for the treatment of large-size tumors previously treated unsuccessfully with various drugs, Onconase effectively showed the inhibition of tumor growth, while cisplatin and carboplatin did not show such tumoricidal effects."
"These studies offer further validation of Onconase's potential as a novel and promising cytotoxic agent," chief executive officer Kuslima Shogen said in the release.
Based in Bloomfield, N.J., Alfacell is a biopharmaceutical company focused on the therapeutics for cancer, using its proprietary ribonuclease technology platform.
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