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Isis Pharmaceuticals, Inc. 1.000% due 11/15/2021

Isis Pharmaceuticals, Inc. 2.750% due 10/1/2019

Isis Pharmaceuticals, Inc. 2.625% due 2/15/2027

Isis Pharmaceuticals, Inc. due 1.5

Isis Pharmaceuticals, Inc.

Isis Pharmaceuticals, Inc. 5.500% due 5/1/2009



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