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Published on 12/30/2005 in the Prospect News Biotech Daily.

Vanda Pharmaceuticals files for $75 million IPO of stock

By Ted A. Knutson

Washington, Dec. 29 - Vanda Pharmaceuticals Inc. filed for a $75 million initial public offering of stock on Thursday.

The Rockville, Md.-based biotechnology company focuses on the development and commercialization of clinical-stage, small molecule product candidates for central nervous system disorders.

The company's portfolio of developmental drugs includes:

• Iloperidone, an atypical antipsychotic for the treatment of schizophrenia and bipolar disorder, which the firm is evaluating in a phase 3 trial for schizophrenia aimed for completion in the first half of 2007.

• VEC-162, a melatonin agonist for the treatment of insomnia and depression, which is entering a phase 3 trial for insomnia and is also ready for phase 2 trials for depression.

• VSF-173, a compound for the treatment of excessive daytime sleepiness, for which Vanda expects to begin a phase 2 trial in the second half of 2006.

IPO proceeds will be used for research, pre-clinical development and clinical trials.

JP Morgan and Banc of America Securities LLC are the joint book runners. Thomas Weisel Partners LLC is a co-manager.

As of Sept. 30, the company had $22.26 million in cash. Vanda had a net loss of $17.0 million on no revenue for the first nine months of 2005 against a loss of $6.3 million on revenue of $34,000 for the first nine months of 2004.

Care Capital Investments II is the leading shareholder with 9.17 million shares for 22.8% of the pre-IPO total. Domain Partners is second with 8.13 million shares for 20.2% of the total.

The company plans to be listed on the Nasdaq under the ticker symbol "VNDA."

The announcement was made in an S-1 registration with the Securities and Exchange Commission.


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