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Nucryst trial of dermatitis cream fails to meet endpoint
By Lisa Kerner
Charlotte, N.C., Sept. 20 - Nucryst Pharmaceuticals Corp. said preliminary top line results from its phase 2 safety and efficacy trial of NPI 32101 in a topical cream formulation, in children and adolescents with atopic dermatitis, showed no significant difference in disease clearance among the three treatment groups.
The treatment groups included 2% NPI 32101 cream, 1% NPI 32101 cream or a placebo cream twice daily for 12 weeks.
In addition, the success rates of both 2% and 1% NPI 32101 creams were statistically identical to that of the placebo.
The study failed to meet its primary efficacy endpoint; however, treatment with NPI 32101 cream was well-tolerated.
Based on preclinical results in a variety of in vitro and in vivo models, the Wakefield, Mass., medical products company said it will continue to develop NPI 32101 for a variety of disease conditions.
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