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Published on 8/1/2006 in the Prospect News Biotech Daily.

GlaxoSmithKline's Lamictal decreases seizures in adolescents, study says

By Elaine Rigoli

Tampa, Fla., Aug. 1 - Data published in the journal Pediatrics suggests that GlaxoSmithKline's lamotrigine (Lamictal) is an effective add-on therapy for the treatment of primary generalized tonic-clonic seizures in a subgroup of children and adolescents.

This randomized, double-blind clinical trial of primary generalized tonic-clonic seizures focused on patients between the ages of two and 20 and showed that Lamictal decreased seizures by 77% versus 40% in the placebo group.

The company said primary generalized tonic-clonic seizures, also known as "grand mal" seizures, are the most common form of generalized seizures, occurring in about 20% of patients with epilepsy. Lamictal is not currently indicated for the treatment of these seizures.

GlaxoSmithKline is a global pharmaceutical company based in London.


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