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Genzyme Campath study in multiple sclerosis meets co-primary endpoint
By Lisa Kerner
Charlotte, N.C., Sept. 14 - Genzyme Corp. said two-year interim results from its phase 2 trial showed that patients taking Campath (alemtuzumab) at high and low doses reported a 75% reduction in the risk of multiple sclerosis relapse compared to patients treated with Rebif (interferon beta-1a).
As a result, the trial met its first co-primary endpoint.
The phase 2 trial randomized 334 patients with active relapsing-remitting multiple sclerosis at 49 medical centers in Europe and the United States.
Genzyme had suspended dosing of alemtuzumab in September 2005 after three patients developed immune thrombocytopenic purpura. The trial remains on clinical hold in the United States, according to the Cambridge, Mass.-based biotechnology company.
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