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EntreMed issued patent for 2-methoxyestradiol analogs through 2020
By Elaine Rigoli
Tampa, Fla., Feb. 14 - EntreMed, Inc. announced Tuesday the issuance of U.S. Patent No. 6,995,278 covering analogs of its lead compound, 2-methoxyestradiol (2ME2 or Panzem).
The patent grants EntreMed composition-of-matter intellectual property protection through 2020 for analogs of 2ME2 in oncology and a broad range of non-oncology indications, including inflammatory and immune disorders, rheumatoid arthritis, and other diseases characterized by abnormal cell division. The patent covers novel antiangiogenic compositions.
Panzem, an antimitotic cancer drug that binds to tubulin and works through multiple cellular pathways, is currently in clinical trials for cancer and preclinical development for inflammatory disorders.
Panzem can attack tumors on multiple fronts - directly by disrupting microtubules, an intracellular matrix necessary for the rapid division of cancer cells (mitosis), by inducing programmed cell death (apoptosis), and by blocking blood vessels that feed tumors (angiogenesis inhibition), according to a company release. Analogs of 2ME2 have been developed by EntreMed to decrease metabolism while retaining their antiproliferative and antiangiogenic properties.
Based in Rockville, Md., EntreMed is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation.
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